yes it is possible to advance through a PowerPoint presentation with animation using a clicker (at least using build sequences works; I've not used whole slide animation e.g. float in, fly in). If the presentation displays correctly in slideshow when you press the space bar or up/down arrows, then it should work in Zionworx. Our vicar builds his sermons and often reveals bullet points using build sequences and these display fine within Zionworx.
We use a simple remote control clicker - "Targus Laser Presentation Remote - USB" (see http://www.ebuyer.com/187940-targus-laser-presentation-remote-usb-amp13eu), but any remote control should work as long as it sends Up/Down key strokes.